Pancreatitis is a complex, progressively destructive inflammatory disorder. Alcohol was long thought to be the primary causative agent, but genetic contributions have been of interest since the discovery that rare PRSS1, CFTR and SPINK1 variants were associated with pancreatitis risk. We now report two associations at genome-wide significance identified and replicated at PRSS1-PRSS2 and X-linked CLDN2 through a two-stage genome-wide study. The PRSS1 variant likely affects disease susceptibility by altering expression of the primary trypsinogen gene. The CLDN2 risk allele is (...) associated with atypical localization of claudin-2 in pancreatic acinar cells. The homozygous CLDN2 genotype confers the greatest risk, and its alleles interact with alcohol consumption to amplify risk. These results could partially explain the high frequency of alcohol-related pancreatitis in men. © 2012 Nature America, Inc. All rights reserved. (shrink)

J. Hillis Miller (1928–2021) was one of the most prominent figures in literary criticism and theory. After receiving his Ph.D. from Harvard University, he taught at Johns Hopkins University, Yale University and the University of California at Irvine. He retired as Professor Emeritus in 2002. Miller was president of the Modern Language Association of America in 1986 and contributed significantly to professional academic institutions and organizations throughout his career. As an important representative of the Yale School, he had close relationships (...) with Derrida, Paul de Man, Geoffrey Hartman and Harold Bloom. Dr. Ning Yizhong did postdoctoral research under his supervision at UCI from 1997 to 1998. This is part of his interviews with Professor Miller during that time. In this interview, Miller talks about the Yale School in general, and Jacques Derrida, Paul de Man and Harold Bloom in particular. 1. (shrink)

It has often been suggested that people’s ordinary folk understanding of morality involves a rejection of moral relativism and a belief in objective moral truths. The results of six studies call this claim into question. Participants did offer apparently objectivist intuitions when confronted with questions about individuals from their own culture, but they offered increasingly relativist intuitions as they were confronted with questions about individuals from increasingly different cultures or ways of life. In light of these data, the authors hypothesize (...) that people do not have a fixed commitment to moral objectivism but instead tend to adopt different views depending on the degree to which they consider radically different perspectives on moral questions. [NOTE: This is a reprint of Sarkissian et al 2011]. (shrink)

The role of analogy appears in surprisingly different areas of the first Critique. On the one hand, Kant considered the concept to have a specific enough meaning to entitle the principle concerned with causation an analogy; on the other hand we can find Kant referring to analogy in various parts of the Transcendental Dialectic in a seemingly different manner. Whereas in the Transcendental Analytic, Kant takes some time to provide a detailed (if not clear) account of the meaning of the (...) term ‘analogy’ and his reasons for his employment of it, in the Transcendental Dialectic on the other hand, Kant’s employment of the term seems far less technical. It would seem on the face of it, that Kant has two senses of ‘analogy’: one technical sense reserved for those constitutive principles of the understanding as laid out in the Analytic, and another casual and commonplace use of the term. This picture, although it contains elements of truth, is ultimately misleading. I argue for three claims in this paper. Firstly, I suggest that there can be found in the first Critique a unified conception of analogy. Secondly, I argue that Kant self-consciously differentiated his employment of analogy from the employment that can be found in many early modern philosophers, e.g. Locke. Thirdly, I will tentatively suggest that this interpretation of analogy can aid us in addressing certain contentious areas of transcendental idealism, most notably the account of causation. (shrink)

A significant effect of China’s rejection of a planned economy for a free market is the stimulus this has given to discussion of therelationship between morality and the market. Some Chinese believe that the introduction of a market economy has had a negative effect on public morality. Others disagree and maintain that it has had only a positive effect. Besides this particular debate there are two others. In the first of these debates, it is maintained on the one side that (...) conduct in the market is amoral and essentially contractual or transactional in nature: a boundary must be drawn between economic conduct and conduct in other spheres of social life. Against this it is argued that ethical norms apply equally to all aspects of social life including the economy. In the second debate one side holds that the market engenders its own “ethical” norms. In opposition it is argued that the moral categories articulated in moral philosophy are applicable to behaviour in the market. (shrink)

The interpretation of transcendental arguments remains a contentious issue for contemporary epistemology. It is usually agreed that they originated in Kant's theoretical philosophy and were intended to have some kind of anti-sceptical efficacy. I argue that the sceptic with whom Kant was concerned has been consistently misidentified. The actual sceptic was Hume, questioning whether the faculty of reason can justify any of our judgements whatsoever. His challenge is a sceptical argument regarding rule-following which engenders a vicious regress. Once this sceptical (...) threat is properly identified, the prospects of transcendental arguments must be re-evaluated. (shrink)

Strawson's philosophical attitude towards scepticism is frequently thought to have undergone a significant shift from the “strong” or “robust” employment of transcendental arguments in Individuals to a more “modest” understanding of the efficacy of such arguments in Skepticism and Naturalism: Some Varieties. I argue that this interpretation is based upon a misunderstanding of the function of transcendental arguments in Strawson's earlier works. Examining the continuity of Strawson's modest naturalistic approach to scepticism can offer some insight as to the continuing overestimation (...) of the anti-sceptical efficacy of transcendental arguments. (shrink)

This article critically evaluates the conception of conscience underlying the debate about the proper place and role of conscience in the clinical encounter. It suggests that recovering a conception of conscience rooted in the Catholic moral tradition could offer resources for moving the debate past an unproductive assertion of conflicting rights, namely, physicians’ rights to conscience versus patients’ rights to socially and legally sanctioned medical interventions. It proposes that conscience is a necessary component of the moral life in general and (...) a necessary resource for maintaining a coherent sense of moral agency. It demonstrates that an earlier and intellectually richer conception of conscience, in contrast with common contemporary formulations, makes the judgments of conscience accountable to reason, open to critique, and protected from becoming a bastion for bigotry, idiosyncrasy, and personal bias. (shrink)

Abstract.In recent issues of Zygon, numerous reflections have been published commenting on where the field of science‐and‐religion has been, where it presently stands, and where it should move in the future. These reflections touch on the importance of the dialogue and raise questions as to what audience the dialogue addresses and whom it should address. Some scholars see the dialogue as prospering, while others point out that much work needs to be done to make the dialogue more accessible to a (...) larger audience and more successful at tackling the provocative questions before us. Other academics view the questions themselves as needing further consideration and focus before answers to them can even be explored. In this article I provide a general overview of these essays by outlining some general categories of thought that seem to emerge from the contributors. I then present some of my own opinions concerning the future of the science‐religion field and emphasize that the dialogue, in addition to its traditional roles, must further the philosophical framework that can aid humanity in resolving the most pressing global concerns of our time. (shrink)

In a recent essay, George Annas, the legal columnist for The New England Journal of Medicine, observed that the resuscitation of extremely premature infants, even over parental objection, is not problematic because “once the child's medical status has been determined, the parents have the legal authority to make all subsequent decisions.” Annas himself is quick to concede that treatment in a high-technology neonatal intensive care unit frequently takes on a life of its own. He also acknowledges that although bioethicists and (...) courts agree that there is no ethical or legal difference between withholding or withdrawing a respirator from a patient, parents and physicians find the withdrawal much more emotionally troubling. (shrink)

Now back in print, and in paperback, these two classic volumes illustrate the scope and quality of Royce'sthought, providing the most comprehensive selection ofhis writings currently available. They offer a detailedpresentation of the viable relationship Royce forgedbetween the local experience of community and thedemands of a philosophical and scientific vision ofthe human situation.The selections reprinted here are basic to any understandingof Royce's thought and its pressing relevanceto contemporary cultural, moral, and religious issues.

This chapter contains sections titled: Introduction Aquinas, Aristotle, and Descriptive Metaphysics Substance and Accident Form, Matter, and Identity Individuation Substance, Causality, and Science Individuals, Universals, and Abstraction Mind and Soul Essence, Existence, and God.

Abstract“NOISE” is a term we are using to describe a complex and distressing aspect of the bodily and cognitive experience of many very ill psychiatric patients. By “noise,” we mean an internally experienced state of crowding and confusion created by a variety of stimuli, the quantity, intensity and unpredictability of which make it difficult for individuals so afflicted to tolerate and organize their experience. Attempts to do so may only add to confusion and psychotic phenomena.

A few years ago philosophy of mind in the main English-language tradition was characterized by marked optimism about progress and by broad agreement that a correct theory would be a version of physicalism that admitted the sui generis nature of psychological descriptions and explanations. Now consensus seems to have given way to chaos supervenient physicalism has become so weak as to be virtually contentless and reductionism has become no more plausible than when it was generally rejected. The essay presses these (...) points and suggests the need of more radical alternatives. (shrink)

I am really quite honored to have a chance to be here. Also let me say how much I appreciate what all of you public health professionals do. One of the unfortunate dimensions of modern American life is that we have chosen to privatize all aspects of life. People do not live on their front porches anymore and watch their neighbors in the evening. They go out back in their wall-enclosed backyards. And we have done the same with medicine.Medicine has (...) been privatized in America. We have lost a sense of the public obligations of health and hygiene and sanitation. So I thank you for keeping the flame alive on what we clearly now know is the far bigger issue of health care in modern society. (shrink)

This text asks what it is to be human. Spectres, cyborgs, clones, aliens - contemporary representations of the inhuman hybrid seem more various, multiform and pressing than ever before. Increasingly the blurred distinction between human and inhuman and the attendant technisation of social life raises a series of opportunities for cultural analysis: both in terms of its current transformative refiguration of body and self and in relation to the narratives, networks and communities within which these new identities are redeployed and (...) enjoyed. In the process of mapping a cultural genealogy which stretches from romanticism to "Neuromancer", this volume examines the impact of science and technology on culture and representation - past, present and future - and resituates the inhuman as a significant contemporary conceptual motif as it resonates across and within the philosophical trajectory of modernity. (shrink)

This article investigates William James's reading of the concepts of selflessness and transcendence in relation to the Chan and Pure Land schools of Chinese Buddhism. The divide between Chan and Pure Land Buddhism may be mediated if we attend to aspects of the two traditions that James found particularly meaningful. James is drawn to selflessness as presented in the concept of emptiness in the Chan understanding of meditative experience. He is equally interested in Buddhist devotional practices of Pure Land that (...) claim to open individuals and their communities to the divine. James saw these two aspects as deeply compatible. (shrink)